Antisense Drug Technology: Principles, Strategies, and - download pdf or read online

By Stanley T. Crooke

ISBN-10: 0824705661

ISBN-13: 9780824705664

broadly revised and up-to-date, Antisense Drug know-how: rules, options, and functions, moment Edition displays the logarithmic development made long ago 4 years of oligonucleotide-based cures, and, specifically, antisense therapeutics and study. reading classes realized from the medical trials of first new release medications, the ebook evaluates the know-how as an entire and provides new instructions and avenues of study and improvement.

Divided into 5 elements, the publication starts with an intensive advent to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. best researchers show the fundamentals of oligonucleotide therapeutics partly through delineating medicinal chemistry, pharmacokinetics, and supply routes comparable to liposomal formulations for nucleic acid delivery.  half 3 info hybridization established medicinal drugs and considers the dramatic advances represented through 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicines. different chemical periods of substances and mechanisms of motion are defined partially 4 with additional discussions on bettering the second one iteration antisense medicines. the ultimate half delves deeply into healing functions. Contributing authors study the potential for antisense medications for the relief of cardiovascular illnesses, metabolic illnesses, inflammatory ailments, melanoma, neurological problems, and immune modulation.

Presenting a hugely particular, lucid dialogue of the awesome advances within the box, Antisense Drug expertise: rules, innovations, and functions, moment Edition offers the platform for researchers to proceed to aggressively pursue the good chance represented by means of this fascinating technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke

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